The aim of this study was an attempt to clarify some of the aspects of the influence of physical exercise on PRL secretion. The study was conducted in three groups. I. In 8 runners (competitors and amateurs), serum PRL was assessed before, after 20 km run, after 30 minutes and following 4 and 24 hours. II. In 18, well fit, students bicycle maximal exercise test was applied. 7 subjects from this group were given orally 500 mg of ASA, about 30 hours prior to the test, the others were given placebo. PRL concentration was measured before, after the end the test and after 30 minutes of recovery. III. Stimulation test with 10 mg of metoclopramide was performed in 7 male competitors (long and middle distance runners), 8 female competitors and in corresponding control groups. PRL concentration was measured at 0, 60, 120 minutes after drug intake. Results of this study revealed that both, aerobic exercise such as 20 km run and short-term maximal bicycle exercise, produce similar, most probably, peak increase in PRL secretion. Single dose of 500 mg ASA leads to a significant decrease in PRL concentration at 30 minutes after short-term intensive exercise. MCP-stimulated increase in PRL concentration is significantly higher in females than males; it is also higher after first hour of test in competitors than in control groups. The increase in PRL concentration after administration of MCP is similar to that observed after intensive physical exercise.
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