Two-week inhalation of budesonide increases muscle Na, K ATPase content but not endurance in response to terbutaline in men
While chronic systemic administration of glucocorticoids increases muscle Na+,K+ ATPase content, such effect is unexplored after therapeutic inhalation. We investigated the effect of therapeutic inhalation of the glucocorticoid budesonide on Na+,K+ ATPase content of skeletal muscle in men. Ten healthy trained subjects, aged 23 ± 4 years (mean ± 95% CI), participated in the study. Before and after 2 weeks of daily inhalation of budesonide (1.6 mg/day), a biopsy was taken from the vastus lateralis muscle for measurement of Na+,K+ ATPase content and blood samples were drawn for determination of plasma budesonide, cortisol, and K+. Subjects' performance during cycling to fatigue at 90% of incremental peak power output (iPPO) was measured in response to 4 mg inhaled terbutaline to maximally stimulate Na+,K+ ATPase activity. Plasma concentrations of budesonide rose to 5.0 ± 1.6 nM with the intervention, whereas no changes were observed in plasma cortisol. Muscle Na+,K+ ATPase content increased (P = 0.01) by 46 ± 34 pmol/(g wet wt) (17% increase) with the intervention. Cycling performance at 90% of iPPO did not change (P = 0.21) with the intervention (203 vs 214 s) in response to terbutaline. The present observations show that therapeutic inhalation of glucocorticoids increases muscle Na+,K+ ATPase content, but does not enhance high-intensity cycling endurance in response to terbutaline.
© Copyright 2016 Scandinavian Journal of Medicine & Science in Sports. Wiley. Kaikki oikeudet pidätetään.
Aiheet: | uupumus kuormitus kestävyyslajit lääkkeet lisäravinteiden käyttö hengitys doping urheilufysiologia lihas lihasfysiologia kestävyys |
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Aihealueet: | biologiset ja lääketieteelliset tieteet |
DOI: | 10.1111/sms.12677 |
Julkaisussa: | Scandinavian Journal of Medicine & Science in Sports |
Julkaistu: |
2016
|
Vuosikerta: | 27 |
Numero: | 7 |
Sivuja: | 684-691 |
Julkaisutyypit: | artikkeli |
Kieli: | englanti (kieli) |
Taso: | kehittynyt |