HFE genotype and endurance performance in competitive male athletes
ntroduction:
Hereditary hemochromatosis can cause individuals to absorb too much iron from their diet. Higher tissue iron content, below the threshold of toxicity, may enhance oxygen carrying capacity and offer a competitive advantage. Single nucleotide polymorphisms (SNP) in the homeostatic iron regulator (HFE) gene have been shown to modify iron metabolism and can be used to predict an individual`s risk of hemochromatosis. Several studies have shown that HFE genotypes are associated with elite endurance athlete status; however, no studies have examined whether HFE genotypes are associated with endurance performance.
Purpose:
The objectives of this study were to determine whether there was an association between HFE risk genotypes (rs1800562 and rs1799945) and endurance performance in a 10-km cycling time trial as well as maximal oxygen uptake (V?O2peak), an indicator of aerobic capacity.
Methods:
Competitive male athletes (n = 100; age = 25 ± 4 yr) completed a 10-km cycling time trial. DNA was isolated from saliva and genotyped for the rs1800562 (C282Y) and rs1799945 (H63D) SNP in HFE. Athletes were classified as low risk (n = 88) or medium/high risk (n = 11) based on their HFE genotype for both SNP using an algorithm. ANCOVA was conducted to compare outcome variables between both groups.
Results:
Individuals with the medium- or high-risk genotype were ~8% (1.3 min) faster than those with the low-risk genotype (17.0 ± 0.8 vs 18.3 ± 0.3 min, P = 0.05). V?O2peak was ~17% (7.9 mL·kg-1·min-1) higher in individuals with the medium- or high-risk genotype compared with those with the low-risk genotype (54.6 ± 3.2 vs 46.7 ± 1.0 mL·kg-1·min-1, P = 0.003).
Conclusion:
Our findings show that HFE risk genotypes are associated with improved endurance performance and increased V?O2peak in male athletes.
© Copyright 2021 Medicine & Science in Sports & Exercise. Lippincott Williams & Wilkins. Kaikki oikeudet pidätetään.
Aiheet: | miespuolinen huippu-urheilu perinnöllisyystiede pyöräily ravitsemus |
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Aihealueet: | biologiset ja lääketieteelliset tieteet |
Tagging: | Eisen Zeitfahren |
DOI: | 10.1249/MSS.0000000000002595 |
Julkaisussa: | Medicine & Science in Sports & Exercise |
Julkaistu: |
2021
|
Vuosikerta: | 53 |
Numero: | 7 |
Sivuja: | 1385-1390 |
Julkaisutyypit: | artikkeli |
Kieli: | englanti (kieli) |
Taso: | kehittynyt |